Structure-function interactions in the therapeutic response of diabetic neuropathy
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چکیده
منابع مشابه
Structure-function interactions in the therapeutic response of diabetic neuropathy.
Conventional electrophysiologic measurements such as nerve conduction velocity, compound action potential, and neuropathic symptom scores have been used to assess the severity of diabetic neuropathy and have been the major efficacy end points following pharmacologic intervention trials. Unfortunately, these measurements are not particularly sensitive and their reproducibility is, at best, good....
متن کاملStructural-functional interactions in the therapeutic response of diabetic neuropathy.
Studies in experimental diabetic rat attribute the acute reversible nerve conduction defect as well as the early structural abnormalities of the node of Ranvier and myelinated axons to changes in nerve metabolism secondary to hyperglycaemia and activation of the pol yo1 pathway.’-8 The early readily reversible slowing of nerve conduction velocity in the diabetic rats correlates with a decrease ...
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ژورنال
عنوان ژورنال: Journal of Diabetes and its Complications
سال: 1992
ISSN: 1056-8727
DOI: 10.1016/1056-8727(92)90051-l